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Past events: Recordings

  • 23 Sep, 2021
  • English
  • 60 minutes
  • Webinar series
Event recordings

Complex regional pain syndrome: Tailored treatment based on phenotyping

Watch Prof. Dr Frank Huygen share his insights about complex regional pain syndrome and discuss tailored treatment based on phenotyping. 

    Webinar Summary

    Prof. Dr Huygen started by introducing the diagnostic criteria and clinical subtypes of CRPS, emphasising the diversity of symptoms associated with this condition. He also highlighted some of the pathophysiological mechanisms known to underlie CRPS, including:

    • Neuroplasticity
    • Inflammation
    • Pain/sensory disturbances
    • Vasomotor disturbances
    • Motor disturbances
    • Psychological disturbances

    Throughout his presentation, Prof. Dr Huygen emphasised the importance of identifying potential underlying factors in driving appropriate therapeutic decision-making. Treatment options for CRPS discussed included:

    • Activation/mobilisation exercises
    • Anti-inflammatory medications
    • Analgetics/co-analgetics
    • Vasodilators
    • Muscle relaxants/spasmolytics
    • Psychological interventions
    • Invasive treatments (spinal cord stimulation/dorsal root ganglion stimulation)

    Following the presentation, Prof. Dr Huygen answered questions from the audience on topics such as the use of sympathetic blocks, ketamine and vitamin C in managing pain (in CRPS) and botulinum toxin to manage dystonia. In response to a question about therapies with limited efficacy in CRPS, he explained that several clinical trials exploring monotherapies have not been successful, as they do not account for the multi-mechanism nature of the condition.


Prof. Dr Ralf Baron

Head of the Division of Neurological Pain Research and Therapy, Christian-Albrecht University of Kiel, Germany

As well as his work at the Department of Neurology, Christian-Albrecht University of Kiel, Prof. Baron serves as a management committee member of the Neuropathic Pain Special Interest Group (NeuPSIG) of the International Association for the Study of Pain (IASP).

Prof. Dr Frank Huygen

Professor of Anaesthesiology, Erasmus MC and University Medical Centre, Utrecht, Netherlands

In addition to his research in CRPS and neuromodulation, Prof. Huygen has chaired the Education Committee of the European Pain Federation (EFIC) since 2020.